PROPHYLACTIC METOCLOPRAMIDE OR TROPISETRON IN PREVENTION OF POSTOPERATIVE NAUSEA AND VOMITING FOLLOWING LAPAROSCOPIC CHOLECYSTECTOMY.

Abstract

Postoperative nausea and vomiting is a common problem after surgery with potentially serious medical complications such as aspiration pneumonia, dehydration and wound ntpture. It may delay discharge from hospital, with obvious economic consequences, and at the very least is distressing to the patients. PONV is multifactorial and depends on patient characteristics, anaesthetic agents, type of surgery and postoperative factors.

The common incidence of PONY was reported in patients undergoing laparoscopic surgery .

This work was carried out to compare the efficacy of the new selective 5- HT3 receptors antagonist (tropisetron) versus metoclopramide in prevention of nausea and vomiting after laparoscopic cholecystectomy. This study was carried out on 60 middle aged patients undergoing laparoscopic surgery with physical status I and II according to (ASA) classification .

THE PATIENTS WERE ALLOCATED INTO 3 GROUPS AS FOLLOWS: Group T: (20 patients) received tropisetron (5 mg I.V.) 5 min. before induction of general anaesthesia. Group M: (20 Patients) received metoclopramide (10mg I.V.) 5 mm.

before induction of general anaesthesia.

Group C: (20 Patients) received placebo I.V. 5 min. before induction of general anaesthesia.