The Value of Transvaginal Ultrasonographic Ovarian Morphology and Insulin Resistance in the Prediction of Clomiphene Citrate Response in Obese Women with Polycystic Ovaries

Abstract

PCOS ts a syndrome of ovarian dysfunction. Its cardinal tealures are hyperandrogenism and polycystic ovanan morphology. Its clinical manifestations may include menstrual irregularities, signs of androgen excess, and obesity. PCOS is associated with an increased risk of type 2 diabetes and cardiovascular diseases. It is well known that obesity is associated with disturbances of reproductive function in women, mainly through insulin resistance. By this mechanism, obesitv may also favor resistance to clomiphene citrate.

Although CC is widely used as one of the pnmary therapy for ovulation induction in patients with PCOS, ovulation cannot be induced by CC in approximately 20% of them. The mechanism of this resistance is still unclear. Based on these preliminary data, the mam objective of the present study was to find a predictor parameter to the CC response in obese

PCOS women in Egypt. / /

For this . purpose, tl)e present study was carried on thirty obese reo .i women in the rep,rdductive age. They received CC to induce ovulation. c. According to the'ovulatory response, they were divided into two groups:

Group I: ovulatory women (:21 women).

GroupII: nonovulatory women (CRA) (9 women).

Statistical analysis of the data obtained t!•om the present study revealed that the majority of Obese Egyptian PCOS women will ovulate in response to CC (70%). The highest ovulatory rate was reached at 150 mg CC (35.29%). Few patients ovulated at 200 mg (9.5%)