Plasma Brain Natriuretic Peptide (BNP) as an Indicator of in hospital Outcome after Acute Myocardial Infarction

Abstract

SUMMARY B -type natriuretic peptide (BNP) is a 32-amino-acid polypeptide secreted by cardiac ventricles in response to increased stretch or wall tension. BNP is involved in the regulation of blood pressure, blood volume and sodium balance. Recent studies have shown that BNP is a useful biochemical marker for cardiac dysfunction. Levels of BNP also appear to be associated with the prognosis of patients with Acute coronary syndromes (ACS). The aim of the study is to investigate the prognostic value of B type natriuretic peptide (BNP) in acute myocardial infarction patients and its correlation with left ventricular function and post-myocardial infarction complications in the in hospital period. This study enrolled 90 consecutive patients admitted to coronary care units of Ain Shams University hospitals with acute ST segment elevation myocardial infarction who successfully reperfused by primary PCI or thrombolysis. The study was performed in the period from September 2014 to April 2015. All patients were subjected to history intake, clinical examination, 12-lead surface ECG, laboratory measurements of BNP immediately after reperfusion an CK-MB level, trans-thoracic echocardiography on third day of admission and in hospital Clinical follow up for: any manifestations of heart failure, Killip class, cardiogenic shock, cardiac arrest, development of pericarditis & mortality, Daily ECG to detect the presence of any arrhythmias (Tachy or Brady) and Cardiac enzymes will be measured daily.