Correlation between on admission serum uric acid level and corrected TIMI frame count, Myocardial Blush Grade in patients with STEMI undergoing primary PCI
Ibrahim Ahmed Mohammed Hazem El-Sawah;
Abstract
SUMMARY
A
cute myocardial infarction is one of the most predominant causes of mortality worldwide, ST-elevation myocardial infarction (STEMI) remains the principle cause of death in developed countries.
Rapid restoration of infarct related arterial (IRA) flow is associated with improved ventricular performance and lower mortality among patients with myocardial infarction. The efficiency of reperfusion therapy in acute myocardial infarction is limited by impaired microvascular reperfusion occurring after opening of an infarct related artery. The impaired coronary flow phenomenon during the acute phase of myocardial infarction has a negative prognostic value. Incomplete coronary reperfusion is associated with a larger infarct size, more frequent congestive heart failure and increased mortality.
Several biomarkers are associated with poorer outcomes in STEMI. High serum uric acid level has been associated with slow coronary flow in patients underwent elective angiography and who underwent primary PCI. It has been also shown as a predictor and an independent risk factor for cardiovascular events and coronary heart disease.
The study was conducted on 120 patients who admitted to the National Heart Institute during the period from January 2015 till June 2015 with acute ST segment elevation myocardial infarction and were treated by primary percutaneous coronary intervention.
Patients were classified into the following groups:
Group 1:
• Patients with normal serum uric acid levels ≤ 7.0 mg/dl for males, and ≤ 6.0 mg/dl for females.
Group 2:
• Patients with high serum uric acid levels > 7.0 mg/dl in males, and > 6.0 mg/dl in females.
All patients were subjected to full history taking, complete physical examination, 12 leads surface ECG, and laboratory investigations including uric acid. Emergency coronary angiography was done and coronary angioplasty was performed accordingly with attention to Myocardial Blush Grade and TIMI Frame count. Also, the severity of CAD in those patients was evaluated using Jeopardy score.
Correlation of patients' serum uric acid levels and post PCI MBG and corrected TIMI frame count was done during the study.
A
cute myocardial infarction is one of the most predominant causes of mortality worldwide, ST-elevation myocardial infarction (STEMI) remains the principle cause of death in developed countries.
Rapid restoration of infarct related arterial (IRA) flow is associated with improved ventricular performance and lower mortality among patients with myocardial infarction. The efficiency of reperfusion therapy in acute myocardial infarction is limited by impaired microvascular reperfusion occurring after opening of an infarct related artery. The impaired coronary flow phenomenon during the acute phase of myocardial infarction has a negative prognostic value. Incomplete coronary reperfusion is associated with a larger infarct size, more frequent congestive heart failure and increased mortality.
Several biomarkers are associated with poorer outcomes in STEMI. High serum uric acid level has been associated with slow coronary flow in patients underwent elective angiography and who underwent primary PCI. It has been also shown as a predictor and an independent risk factor for cardiovascular events and coronary heart disease.
The study was conducted on 120 patients who admitted to the National Heart Institute during the period from January 2015 till June 2015 with acute ST segment elevation myocardial infarction and were treated by primary percutaneous coronary intervention.
Patients were classified into the following groups:
Group 1:
• Patients with normal serum uric acid levels ≤ 7.0 mg/dl for males, and ≤ 6.0 mg/dl for females.
Group 2:
• Patients with high serum uric acid levels > 7.0 mg/dl in males, and > 6.0 mg/dl in females.
All patients were subjected to full history taking, complete physical examination, 12 leads surface ECG, and laboratory investigations including uric acid. Emergency coronary angiography was done and coronary angioplasty was performed accordingly with attention to Myocardial Blush Grade and TIMI Frame count. Also, the severity of CAD in those patients was evaluated using Jeopardy score.
Correlation of patients' serum uric acid levels and post PCI MBG and corrected TIMI frame count was done during the study.
Other data
| Title | Correlation between on admission serum uric acid level and corrected TIMI frame count, Myocardial Blush Grade in patients with STEMI undergoing primary PCI | Other Titles | العلاقة بين مستوى حمض اليوريك في البلازما عند الدخول و عدد الإطارات المصحح للسيولة، ودرجة الإرواء في عضلة القلب المحتشية في المرضى الذين يعانون من الإحتشاء المصحوب بالإرتفاع في معامل ال إس تى والذين سيتم علاجهم بالقسطرة القلبية العاجلة | Authors | Ibrahim Ahmed Mohammed Hazem El-Sawah | Issue Date | 2015 |
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