Clinical and radiological patterns of Multiple Sclerosis among A sample of Egyptian patients.

Abstract

Multiple sclerosis (MS) is a progressive inflammatory disease of the central nervous system. It is the most common cause of neurologic disability in young adults, with onset generally occurring between ages 15 and 40 years old (Fernando, 2009). Our study in Ain Shams University hospitalsfrom January 2012 till April 2014 includes 300 Egyptian MS patients diagnosed according to Revised McDonald criteria 2010 (Polman et al., 2011), showed that 26.7% of cases were males while 73.3% were females. The mean age of our patients was 30.9±8.5, the mean age of onset of disease was 25.69±7.27, the mean duration of illness was 5.28±4.82, the mean EDSS was 3.41± 2.01, the mean Number of relapse was 3.58+2.59 and the mean Number of relapse in last 2 years was 1.63+1.19. As regard family history of the patients there was (4.7%) of patients had family history of MS, and (15.7%) of patients had history of consanguinity.While (3%) of patients had past history of steroid induced DM (onset of DM after onset of MS and related to use of steroid), 3 (1%) had past history of depression. Majority of our patients (85.3%) has age of onset of disease between 18-40 years old, while (11.3%) had onset of disease less than 18 years old and (3.3%) had onset of disease more than 40 years old. RRMS is the most common type of MS in our patients (75.7%) while (17.3%) had SPMS, (2.7%) had PPMS and (4.3%) had PRMS.