Efficacy of Prophylactic Progesterone suppositories in Prevention of Preterm Delivery in Women with Placenta Previa A Randomized Controlled Trial

Abstract

Placenta previa poses a high risk for massive hemorrhage, from the antenatal period until after Cesarean section. This condition increases the risk of maternal and neonatal mortality and morbidity. In cases of placenta previa, the prenatal prediction of sudden bleeding during pregnancy and blood loss during Cesarean section, and the assessment of risk for adherence of the placenta using an ultrasound examination, can improve the perinatal outcome. Previous uterine surgery, particularly delivery by Cesarean section (CS), and maternal age are the principal risk factors. The incidence of placental adherence defects has been estimated. Presumably, the rate increased due to a growing number of CS. There are no symptoms which might signal placental adherence defects. The diagnosis is dependent mostly on clinical suspicion, particularly in case of a total placenta previa or a history of CS. Placenta previa is a demanding clinical condition that complicates 0.3–0.5% of pregnancies. It refers to a placenta that overlies or approximates to the internal os of the cervix. Clinically, it is now commonly accepted that the condition is of clinical relevance when the distance between the lower placenta edge and the internal cervical os is 2 cm.