Evaluation of Serum CXCL10 in Relation to Mini-graft Test in Detecting Stability of Vitiligo
Reham Mohamed Ahmed Hassan;
Abstract
SUMMARY
V
itiligo is an acquired depigmentary disorder of the skin and mucous membranes, due to loss of cutaneous melanocytes or alteration in their function. It is characterized by circumscribed white macules and patches.
Although the pathogenesis of vitiligo is incompletely deciphered, accumulating clinical and laboratory data have indicated that autoimmune responses against melanocytes, especially T cell-based cellular immunity, play important roles in the loss of functional melanocytes in the skin.
Treatment options include medical treatment, surgical treatment, phototherapies & photo-chemotherapies, depigmentation, psychological support and camouflage.
Surgery is indicated for all types of vitiligo that do not respond to medical treatment. Stability status of vitiligo is the single, most important prerequisite in case selection. One or more-year stability has been suggested for better surgery outcome. Stability in vitiligo could not be easily evaluated, due mainly to absence of a reliable serum marker and largely depended on performing a MGT. Recently, the chemokine CXCL-10 has emerged as a putative serum marker that correlated with disease activity.
The aim of this study was to evaluate the serum level of CXCL-10 in patients with ³ 1 year stability an
V
itiligo is an acquired depigmentary disorder of the skin and mucous membranes, due to loss of cutaneous melanocytes or alteration in their function. It is characterized by circumscribed white macules and patches.
Although the pathogenesis of vitiligo is incompletely deciphered, accumulating clinical and laboratory data have indicated that autoimmune responses against melanocytes, especially T cell-based cellular immunity, play important roles in the loss of functional melanocytes in the skin.
Treatment options include medical treatment, surgical treatment, phototherapies & photo-chemotherapies, depigmentation, psychological support and camouflage.
Surgery is indicated for all types of vitiligo that do not respond to medical treatment. Stability status of vitiligo is the single, most important prerequisite in case selection. One or more-year stability has been suggested for better surgery outcome. Stability in vitiligo could not be easily evaluated, due mainly to absence of a reliable serum marker and largely depended on performing a MGT. Recently, the chemokine CXCL-10 has emerged as a putative serum marker that correlated with disease activity.
The aim of this study was to evaluate the serum level of CXCL-10 in patients with ³ 1 year stability an
Other data
| Title | Evaluation of Serum CXCL10 in Relation to Mini-graft Test in Detecting Stability of Vitiligo | Authors | Reham Mohamed Ahmed Hassan | Issue Date | 2018 |
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