Safety & Efficacy of Intermittent Versus Continuous Anticholinergic Medication in Management of Overactive Bladder in Adult

Abstract

The Aim of this study is to compare between the efficacy of continuous anticholinergic therapy and intermitted anticholinergic therapy for the treatment of the overactive bladder. Overactive bladder (OAB) also referred to as the urgency-frequency syndrome, with or without urge urinary incontinence can considerably impair the patient's quality of life. It is widely accepted that diet and life style modifications, behavioural therapy and medication belong to the standard conservative therapeutic options and considered as first-line measures. The International Consultation on Incontinence (ICI) guidelines state that when the first line approach is not fully satisfactory or fails after 8-12 weeks, alternative therapies should be sought out. It is worthwhile and justified to proceed to second-line therapy if patients are refractory to antimuscarinic therapy or if the treatment is contraindicated. Second-line therapies include less-invasive measures such as percutaneous posterior tibial neve stimulation, sacral neuromodulation, detrusor injections with botulin