SIL-2R (CD25) in childhood asthma

Abstract

Current evidence suggests that T lymphocytes may be involved in the regulation and expression of the inflammatory processes associated with bronchial asthma.

Through the action of its wide array of cytokines, these cells may regulate the synthesis of lgE antibody and facilitate the perpetuation of the intense eosinophilic response.

Activation of lymphocytes leads to expression ofiL-2R on cell surface and release of slL-2R molecules into the circulation.

In this work we attempted to evaluate the vanous immunologic parameters encountered in the development of bronchial asthma. For this purpose we carried out this study in chest clinic Ain Shams University during the period between Jan. 1999 and Aug. 2000. It included fifteen acute asthmatic children and fifteen chronic subject. Fifteen healthy children were studied for control.

The patients were evaluated by medical history taking, thorough clinical examination and spirometric assessment of pulmonary functions. Also Laboratory investigation including complete blood count and estimation of serum siL-2R and lgE were done. The percentage of lymphocytes expressing miL-2R for each subject was evaluated using immunoelectron mtcroscopy.