PossibleRoleofL-Carnitine in Improvement of Hepaticand Metabolic Changesin Hyperuricemicand Hyperuricemic-Fructose Supplemented Rats
Amr Hisham ElKady;
Abstract
Introduction: Uricacid,a purinemetabolite, isgenerated bytheactionofthe enzyme, xanthineoxidase (XO), which catalyzes the last two stepsof uricacidformation:hypoxanthineto xanthineandfrom xanthinetouricacid.
Aim of theWork: This studyis designed to throwmorelight on theroleof fructosefeeding in aggravation ofthe possiblemetabolicand hepaticeffectsofhyperuricemia,andtoprobetheability ofL- Carnitineinrestoringtheenergy balanceofthecellandhenceits subsequentability tomanagethepossibledeleteriouseffectsof hyperuricemia.
Materials andMethods: This study was carried out on 50 adult male albino rats, initially weighing150-180grams.Ratswerepurchasedfrom Ophthalmic DiseasesResearchInstitute, Giza, andwerehousedin thePhysiology DepartmentAnimalHouse,Faculty ofMedicine, AinShamsUniversity,under standardconditions of boardingat room temperature 22-25oC,12hourslightdarkcycleandfree access tofood andwater- ad libitum- throughout thewhole period ofthestudy. Ratswere keptinplasticcages(4rats/cage)forone week prior to experimental procedures for acclimatization. Regularmealswereintroduceddaily at8a.m.Ratswerefed standardratdiet(consistedof400mlmilk,600gmbaladybread andvegetablesineachKg).
Results: Asshownin table (1)andfigure(11), plasmauric acid level wassignificantly increasedinuntreatedhyperuricemicrats(group II),untreatedhyperuricemic fructosesupplementedrats(group III),L-Carnitinetreated hyperuricemicrats(groupIV)andL- Carnitine treated hyperuricemic fructose supplemented rats (groupV) comparedtocontrolrats(groupI).
Conclusion:Hyperuricemiacaused deleteriousmetabolicand hepatic effects.Artificialfructose supplementation,in thecurrentstudy, aggravatedthe picture of hyperuricemiaand showedmore deleteriousmetabolicandhepatic effects.
Recommendations:The growing consumption of sweetened beverages containing fructosein developed and developing countries must be controlled and considered asimportant as the animal protein diet in the genesis of hyperuricemia.
Keywords:L-Carnitine, Hepatic and Metabolic, Hyperuricemic, Supplemented Rats
Aim of theWork: This studyis designed to throwmorelight on theroleof fructosefeeding in aggravation ofthe possiblemetabolicand hepaticeffectsofhyperuricemia,andtoprobetheability ofL- Carnitineinrestoringtheenergy balanceofthecellandhenceits subsequentability tomanagethepossibledeleteriouseffectsof hyperuricemia.
Materials andMethods: This study was carried out on 50 adult male albino rats, initially weighing150-180grams.Ratswerepurchasedfrom Ophthalmic DiseasesResearchInstitute, Giza, andwerehousedin thePhysiology DepartmentAnimalHouse,Faculty ofMedicine, AinShamsUniversity,under standardconditions of boardingat room temperature 22-25oC,12hourslightdarkcycleandfree access tofood andwater- ad libitum- throughout thewhole period ofthestudy. Ratswere keptinplasticcages(4rats/cage)forone week prior to experimental procedures for acclimatization. Regularmealswereintroduceddaily at8a.m.Ratswerefed standardratdiet(consistedof400mlmilk,600gmbaladybread andvegetablesineachKg).
Results: Asshownin table (1)andfigure(11), plasmauric acid level wassignificantly increasedinuntreatedhyperuricemicrats(group II),untreatedhyperuricemic fructosesupplementedrats(group III),L-Carnitinetreated hyperuricemicrats(groupIV)andL- Carnitine treated hyperuricemic fructose supplemented rats (groupV) comparedtocontrolrats(groupI).
Conclusion:Hyperuricemiacaused deleteriousmetabolicand hepatic effects.Artificialfructose supplementation,in thecurrentstudy, aggravatedthe picture of hyperuricemiaand showedmore deleteriousmetabolicandhepatic effects.
Recommendations:The growing consumption of sweetened beverages containing fructosein developed and developing countries must be controlled and considered asimportant as the animal protein diet in the genesis of hyperuricemia.
Keywords:L-Carnitine, Hepatic and Metabolic, Hyperuricemic, Supplemented Rats
Other data
| Title | PossibleRoleofL-Carnitine in Improvement of Hepaticand Metabolic Changesin Hyperuricemicand Hyperuricemic-Fructose Supplemented Rats | Other Titles | دور الكارنتين المحتمل فى تحسين التغيرات بوظائف الكبد والايض الناتجه عن زياده حامض اليوريك منفردا او مجتمعا مع تناول شكر الفركتوز بالجرزان | Authors | Amr Hisham ElKady | Issue Date | 2017 |
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