Assessment of vitamin D binding protein in Egyptian cystic fibrosis children and its relation to serum immunoglobulin G
Nivine Abdel Monem El Enbaby;
Abstract
BACKGROUND: Vitamin D binding protein (DBP) is a multifunctional transport protein with a decreased serum concentration in cystic fibrosis (CF).
The aim of the study: is to measure the level of DBP and serum 25-hydroxyvitamin D (25OHD), in order to assess its role as a nutritional marker in CF. In the context of the recently described immunomodulatory functions of vitamin D, the relationship between vitamin DBP and immunoglobulin G (IgG) levels was assessed as well.
METHODS: This is a cross sectional case controlled observational study recruiting 50 patients diagnosed as CF. They were referred to Allergy and Pulmonology Unit, Aboreesh Children’s Hospital, Cairo University, throughout a period of one year for diagnosis, management and follow up. Their age ranged from 18 months to 13 years.Twenty age and sex matched healthy children were included as a control group.DBP and 25OHD were measured using Elisa technique and total IgG was measured using nephelometer method.
RESULTS: CF group had significant lower serum concentrations of DBP p<0.012 and 25OHD p<0.001 while IgG levels were within normal values p<0.216 compared to the control group. Significant positive correlations were observed between IgG and age r=0.528p<0.01 weight r=0.480p<0.001 and height r=0.509p<0.001.Significant positive relations were observed between failure to thrive and DBP p=0.023 and 25OHD p=0.003. Also the study showed a significant positive relation between DBP and pancreatic insufficiency p=0.039.No significant correlations were observed between DBP and age r= 0.030p= 0.836weightr=-0.045p=0.758 and heightr=-0.040p=0.785.No significant correlations were observed between 25OHD and age r=0.126p=0.301 weightr=-0.099p=0.493 and heightr=-0.033p=0.821.No significant correlations were observed between DBP and 25OHD r=-0.224p=0.118between DBP and IgG r=0.195p =0.176 between DBP and sweat chloride testr=0.201p=0.162 and between 25OHD and IgG r=0.195p=0.176.No significant relations were observed between pancreatic insufficiency, and 25OHD p=0.944 and IgG p=0.332and between failure to thriveand IgGp=0.898.
The aim of the study: is to measure the level of DBP and serum 25-hydroxyvitamin D (25OHD), in order to assess its role as a nutritional marker in CF. In the context of the recently described immunomodulatory functions of vitamin D, the relationship between vitamin DBP and immunoglobulin G (IgG) levels was assessed as well.
METHODS: This is a cross sectional case controlled observational study recruiting 50 patients diagnosed as CF. They were referred to Allergy and Pulmonology Unit, Aboreesh Children’s Hospital, Cairo University, throughout a period of one year for diagnosis, management and follow up. Their age ranged from 18 months to 13 years.Twenty age and sex matched healthy children were included as a control group.DBP and 25OHD were measured using Elisa technique and total IgG was measured using nephelometer method.
RESULTS: CF group had significant lower serum concentrations of DBP p<0.012 and 25OHD p<0.001 while IgG levels were within normal values p<0.216 compared to the control group. Significant positive correlations were observed between IgG and age r=0.528p<0.01 weight r=0.480p<0.001 and height r=0.509p<0.001.Significant positive relations were observed between failure to thrive and DBP p=0.023 and 25OHD p=0.003. Also the study showed a significant positive relation between DBP and pancreatic insufficiency p=0.039.No significant correlations were observed between DBP and age r= 0.030p= 0.836weightr=-0.045p=0.758 and heightr=-0.040p=0.785.No significant correlations were observed between 25OHD and age r=0.126p=0.301 weightr=-0.099p=0.493 and heightr=-0.033p=0.821.No significant correlations were observed between DBP and 25OHD r=-0.224p=0.118between DBP and IgG r=0.195p =0.176 between DBP and sweat chloride testr=0.201p=0.162 and between 25OHD and IgG r=0.195p=0.176.No significant relations were observed between pancreatic insufficiency, and 25OHD p=0.944 and IgG p=0.332and between failure to thriveand IgGp=0.898.
Other data
| Title | Assessment of vitamin D binding protein in Egyptian cystic fibrosis children and its relation to serum immunoglobulin G | Other Titles | تقييم علاقة البروتين الحامل لفيتاميند فى الأطفال المصريين المصابين بمرض التليف الحويصلى وعلاقته بمستوى أجسام المناعة ج | Authors | Nivine Abdel Monem El Enbaby | Issue Date | 2015 |
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