Doppler Blood Flow dynamics in the ovarian and uterine arteries in polycystic ovarian disease under induction of ovulation

Abstract

Polycystic ovary disaese is one of the most common endocrinopathies affecting 5 - 10 % of women in reproductive age.( Lakhani, et al, 2002), and although it is by far the most common cause of hyperandrogenic anovulatory infertility and was described more than half a century ago, the underlying cause of this disorder is still uncertain.(Yen ,1999).

The use of B. mode ultrasound helped a lot in diagnosis of PCOD, Doppler ultrasound technique had added a lot for the proper study of vascular changes during the ovarian cycle. Transvaginal sonography with color flow imaging had made it possible to study slight vascular changes during the ovarian cycle. ( Zalud & Kurjak, 1990), (Collins, et al, 1991).

The aim of this work was to study Doppler hemodynamics in ovarian and uterine arteries throughout the ovarian cycle of PCOD patients, ovarian morphology, and graafian follicle blood flow and compare these hemodynamics with the results after induction of ovulation, in correlation with serum hormone levels.

The plan for this study, included twenty PCOD women, all were nulligravida, with primary infertility, with no medical disorders or history of recent drug intake.

All cases were diagnosed as polycystic ovary disease, by a previous history of anovulatory cycles and/or oligomenorrhea, and the presence of polycystic ovaries by transvaginal ultrasound. Diagnosis by ultrasound depended mainly on the presence of many subcapsular atretic follicles arranged around a hyperechoic stoma, and a thick capsule. (Zaidi et al, 1998). After general and local examination, height in metres and weight in kilograms were determined for all of them and body