Chemokines In Dermatology

Abstract

Chemokines are low- molecular weight, basic polypeptides with potent ability to attract and activate leukocytes. They act through a sub­ family of the G-protein-coupled receptors. They can be classified into four subclasses, CXC or alpha-subclass, CC or beta-subclass, C chemokines, and CX)C chemokines. Different chemokines may cause diverse patterns of leukocyte infiltrates observed m different inflammatory skin diseases especially those with an immunological background such as allergic contact dermatitis, psoriasis and atopic dermatitis. Healing of wounds needs recruitment of leukocyte subsets by chemokines. Moreover, the chemokines also contribute to the regulation of epithelialization, tissue remodeling, and angiogenesis. Certain chemokines may play an impotant role in the tumour growth and metastasis. An evidence of specific role of chemokines in mycosis fungoides and melanoma is now available. The chemokine receptor antagonists represent an ongoing and future therapeutic approach for diseases in which chemokines are implicated.