PROLACTIN HORMONE IN SYSTEMIC LUPUS ERYTHEMATOSUS
FATEMAH ALI EL-SHABACY;
Abstract
Prolactin is an anterior pituitary hormone has been known as an immunostimulanl ncuropcpticle. It aJ'JCcts almost every component of the immune system and it is also affected by products of immune system and inflammatory mediators, thus altered PRL level could have a role in the development or the flare up of some autoimmune disease (Berczi, 1992).
Systemic lupus erythematosus (SLE) is a connective tissue autoimmune disease characterized by production of multiple autoantibodies to component ol' cell nucleus in association with multisystem involvement (Daniel eta/., 1997). The initial complaints in early lupus very widely but most 1i•equently include joint pain or swelling (50%) followed by skin rashes (20%) and malaise or fatigue (10-20%) (Snothemer and Gilliam, /992).
The disease predominantly affect women whose age ranging ii•om
15-45 but the disease also diagnosed in females after menopause (Hochberg, 1990). Several factors play a role In the pathogenesis of SLE as environmental, genetic subsceptibility and immune cells disturbances. PRL hormone is one of these factors as it plays a role in pathogenesis and consequently clinical expression of the disease (Jara eta/., 1992).
This study was carried out to assess the frequency of hyperprolactinemia in SLE. We studied twenty SLE patients and ten healthy subjects as a control group. The studied cases fulfilled at least four of the American Collage of Rheumatology revised criteria for the diagnosis of SLE (Tan eta/., 1982).
Systemic lupus erythematosus (SLE) is a connective tissue autoimmune disease characterized by production of multiple autoantibodies to component ol' cell nucleus in association with multisystem involvement (Daniel eta/., 1997). The initial complaints in early lupus very widely but most 1i•equently include joint pain or swelling (50%) followed by skin rashes (20%) and malaise or fatigue (10-20%) (Snothemer and Gilliam, /992).
The disease predominantly affect women whose age ranging ii•om
15-45 but the disease also diagnosed in females after menopause (Hochberg, 1990). Several factors play a role In the pathogenesis of SLE as environmental, genetic subsceptibility and immune cells disturbances. PRL hormone is one of these factors as it plays a role in pathogenesis and consequently clinical expression of the disease (Jara eta/., 1992).
This study was carried out to assess the frequency of hyperprolactinemia in SLE. We studied twenty SLE patients and ten healthy subjects as a control group. The studied cases fulfilled at least four of the American Collage of Rheumatology revised criteria for the diagnosis of SLE (Tan eta/., 1982).
Other data
| Title | PROLACTIN HORMONE IN SYSTEMIC LUPUS ERYTHEMATOSUS | Other Titles | قياس مستوى هرمون البروىكتين فى مرضى الذئبة الحمراء | Authors | FATEMAH ALI EL-SHABACY | Issue Date | 2000 |
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