Effect of Hydroxyurea on Sperm Parameters in Sickle Cell Anemia and Thalassemia Intermedia

Abstract

Thalassemias are genetic disorders in globin chain production. In individuals with Beta -thalassemia, there is either a complete absence of β-globin gene production (β0 -thalassemia) or a partial reduction (β+ -thalassemia). Beta thalassemia is classified into two types depending on the severity of symptoms: thalassemia major and thalassemia intermedia, thalassemia intermediate is usually due to a compound heterozygous state, resulting in anemia of intermediate severity, which typically does not require regular blood transfusions. The patient's hepcidin expression is pathologically suppressed. Hepcidin is a protein, synthesized in the liver, that reduces iron absorption in the body. Hydroxyurea increases fetal hemoglobin which has a