Effect of Vitamin E on Tin-Induced Hepatic Toxicity in Mice

Abstract

Tin is one of the heavy metals that have taken attention in the past three decades. Tin has been of interest as a possible micronutrient found in trace amounts in many tissues and dietary items and reported essential for growth. It is found in industrial application as a metal or compound. The major commercial applications of tin are in food storage containers, solder alloys, tooth paste and in radioactive techniques called Tcgg-tin. Organic tin compounds are used as stabilizers for Polyvinyl chloride (PVC) plastics and also used as biocides<6 ) It is known that, tin deposited in soft tissue was mostly detected in the liver and kidney. Liver in humans was observed to be more important in tin accumulation than kidneys<46) In recent years, environmental pollution from tin and its related compounds has become a serious problem, leading to a toxicological evaluation of tin. The most important detectable effect of tin is to produce free radical species, biological effects, mainly lipid peroxidation. Vitamin E plays a key role in antioxidant defense system. Its main function as antioxidant is protecting tissue lipids from free radical attack.