Non-endoscopic parameters for prediction of esophagogastric varices in Egyptian Patients with Budd Chiari Syndrome

Abstract

he aim beyond this study was to to assess different clinical, biochemical, ultrasonographic and Doppler parameters which might non-invasively predict the presence of esophagogastric varices and PHG in Egyptian Patients with Budd Chiari Syndrome. To fulfill such purpose, 216 patients with confirmed BCS through detailed history taking, clinical examination, and radiological assessment with duplex U/S and laboratory investigations including: liver profile, kidney function tests, complete blood picture and thrombophilia work up. Upper GI endoscopy was conducted to evaluate esophageal and gastric variceal status and PHG. Our results showed that BCS is common among young persons (mean age 27.8±8.1years) and more predominant in female patients than male patients (55.1% versus 44.9% respectively). Most of the patients in our study were diagnosed during the chronic phase of the disease (73.6). Regarding the etiology, we identified combined etiology (multifactorial) in 30.1% of the patients. Factor V Leiden mutation (FVLM) was the most common cause and this was documented in (31.5%) patients. The second most common cause in our series was Antiphospholipid antibody syndrome (APLAS) and this was found in (25.0%) patients.