Study of Fibrotest, NAFLD Fibrosis score, Fibrosis 4 score and Transient Elastography as non invasive tools of liver fibrosis in patients with Non alcoholic fatty liver disease

Abstract

NAFLD is a chronic liver disease characterized by excessive accumulation of fat in the liver. It has a spectrum of disorders including simple steatosis, steatohepatitis, fibrosis, and cirrhosis (Ye et al., 2016). NAFLD is the most common liver disorder in the Western industrialized countries (Basaranoglu et al., 2013). It is closely related to the increased frequency of overweight or obesity. It has recognised association with metabolic syndrome. Central obesity, diabetes mellitus, dyslipidemia are commonest risk factors (Karim et al., 2015). Liver fibrosis is the final pathological result of various chronic liver diseases. (Zhou et al., 2014). Fibrosis is a main prognostic factor that determines the risk of development of liver cirrhosis and its related complications (Younossi et al., 2011). Liver biopsy is considered to be the gold standard for diagnosis of NAFLD as well as differentiating simple fatty liver from non-alcoholic steatohepatitis (Karim et al., 2015).