Comparative Randomized Prospective Study to Evaluate Efficacy and Safety of Tamsulosin Versus Silodosin As Medical Expulsive Therapy For Patients With Distal Ureteral Stones

Abstract

U rolithiasis is one of the commonest urinary tract diseases. Conservative management strategies such as observation or medical expulsive therapy (MET) using alpha blockers to facilitate spontaneous passage of ureteral stones have commonly used during the recent years. The mechanism of action is blockage of adrenergic receptors especially α1-adrenergic receptors in the ureteric smooth muscle cells results in selective relaxation of the ureteric smooth muscle and, therefore, causes ureteric lumen dilatation. The latter phenomenon results in facilitation of stone expulsion. The aim of the present study was to compare the efficacy and safety of silodosin (8mg) vs tamsulosin (0.4mg) as a MET in the management of DUS in term of stone expulsion rate and stone expulsion time, and adverse effects. The present study was a prospective randomized comparative study will be conducted on 60 patients admitted through the outpatient clinic of Urology in Ain shams University Hospitals. The 60 patients divided into two groups each one was 30 patients, first group received tamsulosin 0.4 mg/day for 28 days and the other group received silodosin 8 mg/day for 28 days.