COMPARATIVE STUDY BETWEEN. THE EFFECTS OF CARVEDILOL AND METOPROLOL ON DOXORUBICIN INDUCED NEPHROPATHY

Abstract

The present study was designed to compare the effects of carvedilol and metoprolol on renal function and to detect any protective effect offered by these drugs against renal impairment. The present work showed that carvedilol did not affect the normal renal functions and produced only mild pathological changes in the normal kidneys of rats. Meanwhile, metoprolol produced sodi um retention, hypoalbuminemia and moderate histopathological changes in the normal kidneys of rats during the period of the study. The model of renal impairment used was doxorubicin - induced neph_ropathy. Metoprolol administration one week before and four weeks after induction of . nephropathy did not alter the high levels of the different serum biochemical parameters observed within the model. On the other hand, carved ilol administration one week before and four weeks after induction of nephropath¥ produced a significant improvement on the different serum biochemical parameters. It restored the serum levels of sodium, potassium, creatinine, urea and albumin to normal levels. Moreover, it decreased both seruni .t:tiglycerides and cholesterol. The biochemical and histopathological results of the two tested drugs on doxorubicin­ induced neph ropathy reflected a possible renal sparing and nephroprotective effect for carvedilol compared to metoprolol.