Analytical Study on Certain Polyionic Drugs

Abstract

The thesis consists of five parts Part I: General Introduction and Literature Review This part is divided into two sections: Section A: Introduction. It includes a brief idea about polyionic compounds, their classification, their properties and their presence in biological, environmental and pharmaceutical products. Section B: Literature Review. It includes a review of the structures, the chemical and physical properties of the studied drugs; Cromolyn sodium and Polymyxin B sulphate. Furthermore, it is concerned with different analytical methods reported in literature which aim for the determination of the chosen drugs in pure form, pharmaceutical formulations and biological fluids. Part II: Potentiometric determinations of certain polyionic drugs This part is divided into three sections: Section A: Introduction to ion–selctive electrodes (ISEs). This section describes the theory and the different types of ion selective electrodes. Also, it includes their assembly and their use with other fields.