THE ROLE OF BETA INTEGRINS IN B-CLL CELL SURVIVAL
Nadia Ibrahim Sewelam;
Abstract
B-CLL cells express a variety of adhesion molecules involved in cell cell or cell-matrix interactions (Takuchl & katayama, 1993). However, 8-CLL cells from different patients show a heterogeneous expression, which has been correlated with the disease stages in some studies (De Rossi et al.,
1993; Eksloglu-Demlralp et al., 1996).1nteraction of B-CLL cells with bone
marrow stromal cells is mediated partly by P1 - P2 integrins acting in combination, and contribute to extend the survival of 8-CLL cells. The role of P2 integrins in apoptosis prevention in CLL and their clinical correlation to disease presentation was studied. Nine newly diagnosed CLL cases (Group "A?. 11 CLL cases under treatment and 6 CLL cases with leukemic phase of Non-Hodgkin Lymphoma were enrolled in this study in addition to 18 cases as
a control group. Groups "A", "B" and "C" showed low expression of CD11b with a mean of 9.9 ± 6.9, 20.1 ± 10.1 and 16.5 ± 16.5 respectively,which were statistically non-significant from control group (mean, 14.3 ± 6.3) (P value
0.05). CD95 showed a statistically significant positive correlation with CD11b in the three studied groups. In conclusion lower expression of CD11b and its positive correlation to CD95 confirms its role in 8-CLL cell survival in vivo.
1993; Eksloglu-Demlralp et al., 1996).1nteraction of B-CLL cells with bone
marrow stromal cells is mediated partly by P1 - P2 integrins acting in combination, and contribute to extend the survival of 8-CLL cells. The role of P2 integrins in apoptosis prevention in CLL and their clinical correlation to disease presentation was studied. Nine newly diagnosed CLL cases (Group "A?. 11 CLL cases under treatment and 6 CLL cases with leukemic phase of Non-Hodgkin Lymphoma were enrolled in this study in addition to 18 cases as
a control group. Groups "A", "B" and "C" showed low expression of CD11b with a mean of 9.9 ± 6.9, 20.1 ± 10.1 and 16.5 ± 16.5 respectively,which were statistically non-significant from control group (mean, 14.3 ± 6.3) (P value
0.05). CD95 showed a statistically significant positive correlation with CD11b in the three studied groups. In conclusion lower expression of CD11b and its positive correlation to CD95 confirms its role in 8-CLL cell survival in vivo.
Other data
| Title | THE ROLE OF BETA INTEGRINS IN B-CLL CELL SURVIVAL | Other Titles | ور البيتا إنتجرين في إعاشة الخلايا في سرطان الدم الليمفاوي المزمن " ب " | Authors | Nadia Ibrahim Sewelam | Keywords | .Beta2 integrins- CD11b- CD18 CLL- Lymphoproliferative disorders Apoptosis | Issue Date | 2001 |
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