Comparison between Different Protocols of Prophylactic “Cephradine” Administration In Elective Cesarean Section: Randomized Controlled Trial

Abstract

SUMMARY T he single most important risk factor for postpartum maternal infection is cesarean delivery. A recent prevalence study found that surgical site infection SSIs were the most common healthcare associated infection (HAIs), accounting for 31% of all HAIs among hospitalized patients. While advances have been made in infection control practices, including improved operating room ventilation, sterilization methods, barriers, surgical technique, and availability of antimicrobial prophylaxis, SSIs remain a substantial cause of morbidity, prolonged hospitalization, and death. SSI is associated with a mortality rate of 3%, and 75% of SSI-associated deaths are directly attributable to the SSI. Antibiotic prophylaxis can be expected to produce a significant reduction in the incidence of maternal infectious morbidity. The type of agent used prophylactically as well as the optimal timing of administration have been widely studied and discussed in the literature. Generally prophylactic antibiotics reduce surgical site infections and it is recommended to be administrated prior to surgical incision. As it was recorded by the Centre for Disease Control and Prevention, that it may take as long as 4 hours after maternal administration of many antibiotics to