Study of Presence of Pancreatic Islet Cells Antibodies in A Sample of Egyptian Women with Gestational Diabetes and its Relation to the Development of Type 1 Diabetes Mellitus

Abstract

Gestational diabetes mellitus is defined as carbohydrate intolerance of variable severity with onset or first recognition during the present pregnancy. Gestational diabetes must be considered to be a disease entity that presents significant perinatal risks and carries an enhanced risk for the later development of manifest diabetes in the mother. The appearance of diabetes-related autoantibodies has been shown to be able to predict the development of type 1 diabetes before even hyperglycemia arises, the main one being ICAS . A major issue regarding the presence of ICAs in women with GDM is the potentially increased risk for the development of diabetes either at short term after delivery or at longer follow-up. The majority of reports have agreed that positivity for ICAs during pregnancy increases the maternal risk of glucose intolerance/diabetes. The aim of this study was to asses the prevalence of ICAs among sample of Egyptian females with GDM and relation of prescence of these antibodies to occurance of type 1 diabetes later on.