Alpha adrenergic agonist versus dialysate temperaturemodeling effects on intradialytic hypotension on the same cohort

Abstract

Intradialytic hypotension continues to be a leading problem, especially in the elderly and cardiovascular compromised patients. Intradialytic hypotension does not only cause discomfort, but also increases mortality, according to recent data in which a low post dialytic blood pressure was associated with a significantly increased risk for mortality . The present study was prospective cross over study conducted upon 40 ESRD patient on regular hemodialysis session 3 times per week 4 hour each session on dialysate bicarbonate on Fresenius 4008 machine in AL-Agoza hospital . .Patients were divided into two groups ( A and B) every group consists of 20 patients . Group A: subjected to Two weeks ( six sessions) of hemodialysis with lowering the dialysate temperature to 35° c with measurement of BP every hour during session . Two weeks with midodrine supplementation of 5 mg 30 minutes before each session with measurement of BP every hour during session .