EFFECT OF CONTRAST AGENT ON RENAL FUNCTIONS IN PATIENTS WITH RENAL IMPAIRMENT UNDERGOING PERCUTANEOUS CORONARY INTERVENTION

Abstract

Background C ontrast induced nephropathy is one of the most important clinical complications associated with IV administration of radio-contrast media. This prospective study evaluating incidence and predictors of contrast induced nephropathy after administration of contrast agent in patients with renal impairment undergoing percutaneous coronary intervention. Methods A prospective study that included 100 patient who underwent percutanous coronary intervention with glomerular filtration rate below 90 ml/min. All patients were subjected to full history, examination and investigation. Results were recorded using serum creatinine and glomerluar filtration rate before and 72hours after procedure. Results CIN had occurred in 24% of studied group where these was high incidence of occurrence of CIN with elderly (p=0.009), obese patients (p=0.039), hypertensive (p=0.004), Diabetics (p=0.000) and amount of dye received (p=0.000). Conclusion High incidence of CIN in our populations with increase risk with age, weight, hypertension, diabetes and amount of dye received. Recommendations in order to prevent CIN: 1) Proper and accurate control of diabetes mellitus 2) Proper and accurate control of hypertension 3) Usage of low amount of contrast dye as possible 4) Cessation of smoking 5) Usage of N – Acety cysteine 6) Proper hydration with saline before and after the procedure 7) Reduction of patients weight might be helpful 8) Choose proper type of contrast dye to be used 9) Proper and accurate control of the renal functions by a nephrologist.