PHARMACOLOGICAL STUDY OF SOME ANTI-INFLAMMATORY, ANTI-OXIDANTS AND ANTI-DIABETIC DRUGS
YASSER NOUR ELDIN EL SAID ABOU EL NOUR;
Abstract
SUMMARY & CONCLUSION
In the present study, biomarkers of oxidative stress, namely, blood Glutathione (GSH) level, serum malondialdehyde (MDA) level and blood superoxide dismutase (SOD) activity as well as the markers of the diabetic state, serum glucose and insulin levels were measured in normal and STZ-diabetic control groups as well as STZ-diabetic rats treated with either gliclazide, rosiglitazone , selenium, diclofenac sodium or Nigella sativa oil .
Also to investigate the possible interactions between the aforementioned dmgs , the previous parameters were estimated in STZ diabetic rats with both the co-administration of gliclazide and either rosiglitazone, nigella, selenium or diclofenac sodium , and the co administration of gliclazide and rosiglitazone with either of nigella, selenium, or diclofenac sodium .
The following are the conclusions :
o Administration of gliclazide, rosiglitazone, selenium, diclofenac sodium or nigella sativa oil abolished the increase in serum glucose level in STZ- diabetic rats .
o Administration of gliclazide antagonized the decrease m serum
insulin level caused in STZ- diabetic rats .
o Neither rosiglitazone, selenium, diclofenac sodium nor nigella sativa did any significant change in serum insulin level of STZ- diabetes rats.
204
In the present study, biomarkers of oxidative stress, namely, blood Glutathione (GSH) level, serum malondialdehyde (MDA) level and blood superoxide dismutase (SOD) activity as well as the markers of the diabetic state, serum glucose and insulin levels were measured in normal and STZ-diabetic control groups as well as STZ-diabetic rats treated with either gliclazide, rosiglitazone , selenium, diclofenac sodium or Nigella sativa oil .
Also to investigate the possible interactions between the aforementioned dmgs , the previous parameters were estimated in STZ diabetic rats with both the co-administration of gliclazide and either rosiglitazone, nigella, selenium or diclofenac sodium , and the co administration of gliclazide and rosiglitazone with either of nigella, selenium, or diclofenac sodium .
The following are the conclusions :
o Administration of gliclazide, rosiglitazone, selenium, diclofenac sodium or nigella sativa oil abolished the increase in serum glucose level in STZ- diabetic rats .
o Administration of gliclazide antagonized the decrease m serum
insulin level caused in STZ- diabetic rats .
o Neither rosiglitazone, selenium, diclofenac sodium nor nigella sativa did any significant change in serum insulin level of STZ- diabetes rats.
204
Other data
| Title | PHARMACOLOGICAL STUDY OF SOME ANTI-INFLAMMATORY, ANTI-OXIDANTS AND ANTI-DIABETIC DRUGS | Other Titles | دراسه فارماكولوجيه عن بعض مضاداتالاكسده والادويه المستعمله فى علاج الالتهاب ومرض السكر | Authors | YASSER NOUR ELDIN EL SAID ABOU EL NOUR | Issue Date | 2010 |
Recommend this item
Similar Items from Core Recommender Database
Items in Ain Shams Scholar are protected by copyright, with all rights reserved, unless otherwise indicated.