Serum Levels of Zinc and Copper in Cases of Juvenile Rheumatoid Arthritis

Abstract

JRA represents a heterogeneous group of autoimmune diseases. It arises before 16 years of age and lasts more than 6 months. During acute inflammation serum copper concentration increases and zinc decreases. This observation led to speculation on the possible pharmacological properties of these trace elements. Aim: the aim of this study was to measure the serum level of zinc and copper in patients with juvenile rheumatoid arthritis (JRA) with different subtypes and correlate the levels of zinc and copper with the disease activity. Methods: This is a cross-sectional study was done on 40 patients already diagnosed clinically with JRA and were followed-up at the Rheumatology Outpatient Clinic, Children's Hospital, Cairo University. Results: Out of forty patients, 16 were males (40%) and 24 were females (60%) with a male to female ratio (M: F) of 2:3. Out of the forty patients 17 were in activity and 23 were without activity. Thirty age and sex matched controls were included for comparison. Conclusion: Serum copper levels were significantly higher in patients with JRA than those of the controls (P= 0.017) while there were no significant difference in serum levels of zinc between JRA patients and that of the controls.