PROSTATIC SPECIFIC ANTIGEN-NEW APPLICATIONS IN BREAST AND OTHER TUMOURS
Doaa Ahmed EI-Awady;
Abstract
The original serum marker used for prostate cancer assessment was prostatic acid phosphatase (PAP). It was used as an indicator of metastatic prostate cancer and had no role in the diagnosis of organ confined prostate cancer. An elevated PAP was not always assosciated with metastatic prostate cancer. Therefore, its clinical value was somewhat limited (Clements, 1999).
Prostatic specific antigen (PSA) is one of the most valuable tumor markers widely used for the detection and diagnosis of prostatic carcinoma and for the surveillance of recurrent disease following prostatectomy. It has also proved to be useful diagnostic tool distinguishing a prostatic primary from other metastatic adenocarcinoma (Fan et al., 2000).
Although highly specific and once considered to be exclusively secreted by the epithelial cells lining the acini and ducts of the prostate (Armbruster, 1993), there is increasing evidence that PSA can be detected immunohistochemically in a variety of steroid hormone stimulated, normal, and malignant epithelial tissues. Among these include normal skin adenexa, perineal apocrine sweat glands (Fan et al., 2000), periurethral glands (Diamandis and Yu, 1997), perianal glands (Kamoshida and Tsutsumi, 1990), renal cell carcinoma (Pummer et al., 1992), salivary duct carcinoma, sweat gland carcinoma, aporcine breast carcinoma, bladder carcinoma, colon and bile duct carcinomas (Fan et al., 2000).
Prostatic specific antigen (PSA) is one of the most valuable tumor markers widely used for the detection and diagnosis of prostatic carcinoma and for the surveillance of recurrent disease following prostatectomy. It has also proved to be useful diagnostic tool distinguishing a prostatic primary from other metastatic adenocarcinoma (Fan et al., 2000).
Although highly specific and once considered to be exclusively secreted by the epithelial cells lining the acini and ducts of the prostate (Armbruster, 1993), there is increasing evidence that PSA can be detected immunohistochemically in a variety of steroid hormone stimulated, normal, and malignant epithelial tissues. Among these include normal skin adenexa, perineal apocrine sweat glands (Fan et al., 2000), periurethral glands (Diamandis and Yu, 1997), perianal glands (Kamoshida and Tsutsumi, 1990), renal cell carcinoma (Pummer et al., 1992), salivary duct carcinoma, sweat gland carcinoma, aporcine breast carcinoma, bladder carcinoma, colon and bile duct carcinomas (Fan et al., 2000).
Other data
| Title | PROSTATIC SPECIFIC ANTIGEN-NEW APPLICATIONS IN BREAST AND OTHER TUMOURS | Other Titles | المولد المضاد الخاص بالبروستاتا فى أورام الثدى والأورام الأخرى | Authors | Doaa Ahmed EI-Awady | Issue Date | 2001 |
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