Novel study of some drugs and their complexes with certain transition metals “synthesis, characterization and biological activity”

Abstract

Candidate Name: Hoda Ahmed Mohamed Elsawy Title of Thesis: Novel study of some drugs and their complexes with certain transition metals “synthesis, characterization and biological activity” Degree: (Ph.D): The Ph.D of Science in Inorganic Chemistry, Faculty of Science, Ain Shams University, 2017. Two novel Schiff bases of (trans-4-[(2-(2-hydroxybenzimino)-3,5-dibromobenzyl)amino]cyclohexanol) (H2L1) and (trans-4-[(2-(2-quinolinoimino)-3,5-dibromobenzyl)amino]cyclohexanol) (HL2) with their complexes with Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II), Cd(II) La(III), Er(III) and Yb(III) were sensitizes and characterized by using many analytical techniques including elemental analyses, mass spectroscopy, IR, 1H NMR, magnetic moment, molar conductance and thermal analyses. The prepared complexes were found to have octahedral geometry. The biological activity (antimicrobial and anticancer activities) of the ligands and their complexes were also screened.