DE.RMABRASION FORTH£ TREATMENT OF LOCAUZED VITIU60 WITH AND WITHOUT APPUCATION OF 5% 5- FLUOROURACIL

Abstract

Vitiligo is a common acquired disorder and occurs in about 1•% of the world population. It is presented as patchy white depigmented lesions which gradually progress over many years. It occurs at any age but 70 to 80% of cases occur below the age 30 years.

There are various hypotheses for the pathogenesis of vitiligo the most accepted included genetic, neurogenic, autoimmune and melanocyte self destruction hypotheses. vitiligo can be classified into:

1- Localized which may be local (focal) or segmental.

2- Generalized which may be acroficial, vulgaris and universalis.

3- Mixed.

Different methods of treatment have been used 111 treatment of vitiligo which included: 1- Photochemotherapy:

- PUVA

- Khellin+ UVA

II- Corticosteroid therapy (mainly topical steroids).

III- Surgical treatment which included many modalities:

I" Dermabrasion with 5-fluorouracil topical application.

2- Grafting techniques: Like minigrafting, epidermal sheets grafting and melanocyte transplantation.