Evaluation of Thresholds for White Blood Cell Specific Flags on Sysmex XN 1000 Hematology Analyzer
Christine Helmy Hakim Barsoum;
Abstract
The complete blood count (CBC) is one of the most commonly ordered blood tests in clinical practice.
Although it is theoretically desirable for every blood count to include examination of a stained film, this has become impossible as a result of increasing workloads; time- and cost-effective rationalization has therefore been required. This has been helped by the availability of automated analyzers that report differential leucocyte counts on every specimen. Consequently, significantly fewer blood films are now examined microscopically.
Thus, a decision of when a blood film should be made, stained and examined should take account of flagging and the need to ensure analytic reliability. This includes a check of any significant changes from a recent previous count (delta check), as well as any specific clinical circumstances.
Most automated cell counters are installed with factory-set or factory-recommended settings for the thresholds. It is then up to the individual laboratories to adjust the thresholds to the clinical needs of their patients and clinical staff variable.
Therefore, a careful optimization of cutoffs to balance the risk of non detection of pathologic cells with laboratory efficiency is needed
Sysmex XN series has the following suspect flags “Blast/Abn lymph”, “Left Shift”, “IG” and “Atypical lymph”.
Although it is theoretically desirable for every blood count to include examination of a stained film, this has become impossible as a result of increasing workloads; time- and cost-effective rationalization has therefore been required. This has been helped by the availability of automated analyzers that report differential leucocyte counts on every specimen. Consequently, significantly fewer blood films are now examined microscopically.
Thus, a decision of when a blood film should be made, stained and examined should take account of flagging and the need to ensure analytic reliability. This includes a check of any significant changes from a recent previous count (delta check), as well as any specific clinical circumstances.
Most automated cell counters are installed with factory-set or factory-recommended settings for the thresholds. It is then up to the individual laboratories to adjust the thresholds to the clinical needs of their patients and clinical staff variable.
Therefore, a careful optimization of cutoffs to balance the risk of non detection of pathologic cells with laboratory efficiency is needed
Sysmex XN series has the following suspect flags “Blast/Abn lymph”, “Left Shift”, “IG” and “Atypical lymph”.
Other data
| Title | Evaluation of Thresholds for White Blood Cell Specific Flags on Sysmex XN 1000 Hematology Analyzer | Authors | Christine Helmy Hakim Barsoum | Issue Date | 2017 |
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