EFFECT OF ROSEMARY EXTRACTS ON DIABETIC AND LIVER MALFUNCTIONAL RATS

Abstract

This study was achieved to evaluate (i) the therapeutic effects of alcoholic, aqueous extracts and oil of rosemary on acute hyperglycemia induced by streptozotocin (STZ) in male rats, (ii) The protective effects of alcoholic, aqueous and oil extracts of rosemary on liver toxicity induced by CCl4 in male rats. The protective and therapeutic effects of these plant extracts compared to the adverse effects of CCl4 or STZ were monitored through different blood biochemical assays and histological examinations of liver and pancreas tissues. The therapeutic effects of rosemary alcohol, aqueous extracts and oil were noticed by gradual decreasing levels of fasting and postprandial blood glucose in diabetic rats treated with these extracts or oil compared to untreated diabetic rats. Histological examinations of pancreas of rats from the negative control group revealed the normal histological structure of pancreatic parenchyma. In contrary, pancreas of rats treated with STZ showed vacuolation of epithelial lining pancreatic acini and vacuolation of cells of islets of Langerhan’s. The rats treated with STZ plus extracts of rosemary or oil didn't have histopathological changes noticed in pancreas. The protective effects of rosemary extracts and oil against liver toxici