EXPRESSION OF CD98 (CAF7) AND bcl-2 IN ACTE LEUKEMIA AND THEIR PROGNOSTIC if
Iman Mahmoud Al-Zoghby;
Abstract
Deregulation of apoptosis which is a physiologic, tightly regulated process may contribute to the development of malignant state by permitting the expansion of cells capable of genetic progression to malignancy.
The Bcl-2 gene family constitutes one of the most critical groups of apoptosis regulators genes. Overexpressed Bcl-2 protein antagonizes apoptosis induced by a number of different stimuli, including anticancer drugs. This overexpression contribute to cell accumulation and malignant transformation.
The CD98 is a 125 KD type II transmemberane glycoprotein. CD98 is strongly expressed on all activated, malignant and transformed cells, while low levels of this molecules are expressed on resting peripheral blood mononuclear cells. Moreover CD98 is a target structure for natural killer (NK) cell activity and is directly involved in the process of cell renewal and apoptosis
The purpose of the present study was to assess the expression of Bcl-2 and CD98 in acute leukemia patients together with measurement of DNA index, and to evaluate their influence on the clinical outcome of patients.
This study was conducted on 59 newly diagnosed patients with acute leukemia, (37 ALL cases and 22 AML cases)
The Bcl-2 gene family constitutes one of the most critical groups of apoptosis regulators genes. Overexpressed Bcl-2 protein antagonizes apoptosis induced by a number of different stimuli, including anticancer drugs. This overexpression contribute to cell accumulation and malignant transformation.
The CD98 is a 125 KD type II transmemberane glycoprotein. CD98 is strongly expressed on all activated, malignant and transformed cells, while low levels of this molecules are expressed on resting peripheral blood mononuclear cells. Moreover CD98 is a target structure for natural killer (NK) cell activity and is directly involved in the process of cell renewal and apoptosis
The purpose of the present study was to assess the expression of Bcl-2 and CD98 in acute leukemia patients together with measurement of DNA index, and to evaluate their influence on the clinical outcome of patients.
This study was conducted on 59 newly diagnosed patients with acute leukemia, (37 ALL cases and 22 AML cases)
Other data
| Title | EXPRESSION OF CD98 (CAF7) AND bcl-2 IN ACTE LEUKEMIA AND THEIR PROGNOSTIC if | Other Titles | دراسة سى . دى . 98 وبروتين بى . سى . ال 2 فى حالات سرطان الدم الحاد وعلاقتهما بتطور المرض | Authors | Iman Mahmoud Al-Zoghby | Issue Date | 2001 |
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