Effect of Diet Regimen Rich in Vitamin C on Iron Overload in Children with Beta Thalassemia Major
Omar Mohsen Saleh Elalfy;
Abstract
O
xidative damage by reactive oxygen species (generated by free globin chains and labile plasma iron) is believed to be one of the main contributors to cell injury, tissue damage, and hypercoagulability in patients with thalassaemia. Treatment with antioxidants, in mono- or combination therapy, may thus neutralize the deleterious effects of reactive oxygen species. Vitamin C is known to increase efficacy of DFO as an iron chelator.
In view of this data, this study aimed to asses the efficacy and safety of administration of vitamin C on different iron chelation therapy in children and adolescent with β-Thalassemia major.
This cohort study included 100 patients with β-thalassemia major (β-TM) recruited from the regular attendants of the Pediatric Hematology Clinic, Pediatric Hospital, Ain Shams University from October 2013 to April 2014.
Patients with β-thalassemia major as defined by complete blood count (CBC), reticulocytic count and markers of chronic hemolysis as well as hemoglobin analysis by hemoglobin analysis using high performance liquid chromatography (HPLC). Patients with serum ferritin > 2500 or those with diabetes, clinical cardiac disease, advanced liver disease were excluded.
xidative damage by reactive oxygen species (generated by free globin chains and labile plasma iron) is believed to be one of the main contributors to cell injury, tissue damage, and hypercoagulability in patients with thalassaemia. Treatment with antioxidants, in mono- or combination therapy, may thus neutralize the deleterious effects of reactive oxygen species. Vitamin C is known to increase efficacy of DFO as an iron chelator.
In view of this data, this study aimed to asses the efficacy and safety of administration of vitamin C on different iron chelation therapy in children and adolescent with β-Thalassemia major.
This cohort study included 100 patients with β-thalassemia major (β-TM) recruited from the regular attendants of the Pediatric Hematology Clinic, Pediatric Hospital, Ain Shams University from October 2013 to April 2014.
Patients with β-thalassemia major as defined by complete blood count (CBC), reticulocytic count and markers of chronic hemolysis as well as hemoglobin analysis by hemoglobin analysis using high performance liquid chromatography (HPLC). Patients with serum ferritin > 2500 or those with diabetes, clinical cardiac disease, advanced liver disease were excluded.
Other data
| Title | Effect of Diet Regimen Rich in Vitamin C on Iron Overload in Children with Beta Thalassemia Major | Other Titles | تأثير النظام الغذائى الغنى بفيتامين ج على مخزون الحديد الزائد فى أطفال انيميا البحر المتوسط العظمى | Authors | Omar Mohsen Saleh Elalfy | Issue Date | 2014 |
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