Migraine Co morbidity in Patients with Multiple Sclerosis
Ghada Ashraf Ahmed;
Abstract
Multiple sclerosis is an immune-mediated chronic disorder of the central nervous system in young adults, characterized by a spatial and temporal dissemination of the pathological process, with multiple areas of inflammation, demyelination, and glial sclerosis are observed in the white matter. Various symptoms and signs occur due to the affected areas in the brain and the spinal cord.
Migraine is a complex, common, and disabling disorder of the brain, which is characterised by recurrent attacks of pulsationg moderate to severe headache associated with sensory symptoms pain and sensitivity to normal afferent information, such as light, sound, and head movement , in which both central and peripheral components of
The trigeminal pain pathway probably plays a significant role, both in the symptoms and signs of the attack and in the mechanisms of action of antimigraine compounds.
Migraine headache is a common feature in MS patients with variable prevalence among the studies 1.6–28.5% up to 60%. It can influence the diagnosis, radiological evaluation, treatment, and quality of life of these patients. Similarities in symptoms between patients with migraine and MS presenting with headache can lead to misdiagnosis. Likewise, MRI lesions which may be found in migraine patients without other neurological symptoms or signs may cause diagnostic confusion and patient anxiety.
Studies addressing the pathophysiology of these comorbid conditions have not found a clear link, but brain stem lesions during the inflammatory processes, changes in the cytokines during the relapse , alternation in BBB permeability during migraine attacks and disease-modifying agents mode of action and side effect profiles have been proposed as possible association factors . Thorough evaluation of headache especially migraine headache in patients with MS is crucial to optimize patient management to help improve quality of life. Management of de novo or treatment-induced headache in the MS patient is fairly straightforward if the physician is aware of the problem
Migraine is a complex, common, and disabling disorder of the brain, which is characterised by recurrent attacks of pulsationg moderate to severe headache associated with sensory symptoms pain and sensitivity to normal afferent information, such as light, sound, and head movement , in which both central and peripheral components of
The trigeminal pain pathway probably plays a significant role, both in the symptoms and signs of the attack and in the mechanisms of action of antimigraine compounds.
Migraine headache is a common feature in MS patients with variable prevalence among the studies 1.6–28.5% up to 60%. It can influence the diagnosis, radiological evaluation, treatment, and quality of life of these patients. Similarities in symptoms between patients with migraine and MS presenting with headache can lead to misdiagnosis. Likewise, MRI lesions which may be found in migraine patients without other neurological symptoms or signs may cause diagnostic confusion and patient anxiety.
Studies addressing the pathophysiology of these comorbid conditions have not found a clear link, but brain stem lesions during the inflammatory processes, changes in the cytokines during the relapse , alternation in BBB permeability during migraine attacks and disease-modifying agents mode of action and side effect profiles have been proposed as possible association factors . Thorough evaluation of headache especially migraine headache in patients with MS is crucial to optimize patient management to help improve quality of life. Management of de novo or treatment-induced headache in the MS patient is fairly straightforward if the physician is aware of the problem
Other data
| Title | Migraine Co morbidity in Patients with Multiple Sclerosis | Other Titles | الاعتلال المشترك بين الصداع النصفي و مرض التصلب العصبي المتعدد | Authors | Ghada Ashraf Ahmed | Issue Date | 2014 |
Recommend this item
Similar Items from Core Recommender Database
Items in Ain Shams Scholar are protected by copyright, with all rights reserved, unless otherwise indicated.