Acute liver injury during pregnancy in ICU
Wesam Abdallah Ibrahim;
Abstract
The pregnant woman experiences physiological changes to
support fetal growth and development. During the pregnancy serum
estrogens and progesterone levels increase progressively and reach a
maximum during the third trimester. These sex steroids have effects
on metabolic, synthetic and excretory hepatic function.
Pregnancy has little effect on a normal liver. There are no
significant changes in liver function during pregnancy, but some
markers of liver function may alter slightly. For example, alkaline
phosphatase may go up modestly as the pregnancy advances, due to
its production by a normal placenta. Blood levels of albumin will
decrease because of the dilution of an expectant mother’s blood.
However, any abnormalities in standard tests (bilirubin,
aminotransferase, or prothrombin time) should be considered an
indication of possible liver problems.
Liver disease that occurs during pregnancy can present a
challenge for health care providers. Certain liver diseases are
uniquely associated with pregnancy, whereas others are unrelated.
The liver diseases unique to pregnancy include acute fatty liver of
pregnancy, intrahepatic cholestasis of pregnancy, Hemolysis and
Elevated Liver enzymes and Low Platelets (HELLP) syndrome and
hyperemesis gravidarum,. Liver disease such as acute viral hepatitis
can occur in pregnancy, and pregnancy may occur in a patient with
underlying chronic liver disease, including patients with cirrhosis
support fetal growth and development. During the pregnancy serum
estrogens and progesterone levels increase progressively and reach a
maximum during the third trimester. These sex steroids have effects
on metabolic, synthetic and excretory hepatic function.
Pregnancy has little effect on a normal liver. There are no
significant changes in liver function during pregnancy, but some
markers of liver function may alter slightly. For example, alkaline
phosphatase may go up modestly as the pregnancy advances, due to
its production by a normal placenta. Blood levels of albumin will
decrease because of the dilution of an expectant mother’s blood.
However, any abnormalities in standard tests (bilirubin,
aminotransferase, or prothrombin time) should be considered an
indication of possible liver problems.
Liver disease that occurs during pregnancy can present a
challenge for health care providers. Certain liver diseases are
uniquely associated with pregnancy, whereas others are unrelated.
The liver diseases unique to pregnancy include acute fatty liver of
pregnancy, intrahepatic cholestasis of pregnancy, Hemolysis and
Elevated Liver enzymes and Low Platelets (HELLP) syndrome and
hyperemesis gravidarum,. Liver disease such as acute viral hepatitis
can occur in pregnancy, and pregnancy may occur in a patient with
underlying chronic liver disease, including patients with cirrhosis
Other data
| Title | Acute liver injury during pregnancy in ICU | Other Titles | إصابات الكبد الحادة أثناء الحمل بالرعاية المركزة | Authors | Wesam Abdallah Ibrahim | Issue Date | 2013 |
Recommend this item
Similar Items from Core Recommender Database
Items in Ain Shams Scholar are protected by copyright, with all rights reserved, unless otherwise indicated.