DNA Segregation and Related Biochemical_ Parameters in Normal and Leukemic Population

Abstract

Cancer is the second leading cause of childhood death. Leukemia is the most common malignancy of childhood and acute lymphoblastic leukemia (ALL) is the most common type of leukemia in children. Annual incidence of ALL is about 30 cases per million population, with a peak incidence in patients aged 2-5 years. Early symptoms of ALL are difficult to detect, since they are nonspecific and may mimic those of viral infections. Acute leukemia usually has a sudden onset and rapid progress from early signs. Studies of cytogenetic and molecular genetics of childhood leukemia will significantly improve the ability of clinicians to predict therapeutic response and prognosis, which paves the way for risk stratification based on clinical and genetic features.