Alpha-fetoprotein Level as a Predictor of Hepatocellular Carcinoma Recurrence after Adult Living donor Liver Transplantation within Milan criteria

Abstract

SUMMARY H epatocellular carcinoma is a primary cancer of the liver and occurs predominantly in patients with underlying chronic liver disease and cirrhosis. The treatment of HCC include Resection, Liver transplantation, Percutaneous radio frequency ablation (RFA), Microwave coagulation therapy (MCT), Transarterial chemoembolization (TACE), Sorafenib, and Sunitinib. Liver transplantation is considered the optimal therapy for end stage liver disease & HCC. The value of an elevated pretransplantation AFP level has a good predictive value of HCC recurrence after Iiver transplantation. This study was conducted in Ain Shams Specialized Hospital to evaluate Alpha fetoprotein as a predictor of HCC recurrence after Liver transplantation. It included 75 patients underwent Liver transplantation for HCC, recurrence occurred in 6.7% of patients. pretransplantation Alpha fetoprotein was higher in patients with HCC recurrence after liver transplantation.