APITHERAPY IN TREATMENT OF PSC RIASIS :A-NEW THERAPEUTIC MODALITIES

Abstract

Psoriasis is a chronic, inflammatory, hyperproliferative skin disease that characterized clinically by indurated, erythematous scaling plaques most commonly located on the extensor aspects of the elbows and knees, and scalp, but any skin site may be affected . The pathogenesis of psoriasis is linked to activation of T-cells and several types of leucocytes that control cellular immunity through induction of different inflammatory cytokines and chemokinesr. A variety of approaches are available for the treatment of psoriasis, ranging from topical agents for milder forms of the disease to phototherapy and systemic agents for severe psoriasisr . Apitherapy is the medicinal use of various products of honey bee including raw honey, pollen, royal jelly, wax, propolis and venom. Apitherapy cite the benefits of bee venom and propolis for treating many ailments including rheumatic diseases, neurological diseases as multiple sclerosis,and dermatological conditions as eczema, psoriasis, and herpes virus infectionr. Bee venom secreted from venom gland in the late area of the worker bee. The main components of it include: peptides as mellitin, apamin, mast cell degranulation peptide-40l(MCD-peptide), enzymes as hyaluronidase, and non peptide component as glucose, and fructoser......