Ultrasonographic Scoring System Score Versus Liver Stiffness Measurement Compared to Histopathological Findings in Diagnosis of Cirrhosis in HCV Infected Egyptian Patients

Abstract

Chronic hepatitis C infection represents a major cause of liver related morbidity and mortality. Egypt ranked number 1 worldwide in the prevalence of chronic hepatitis C. But great efforts are going on to improve diagnosis and treatment of those patients. Noninvasive methods for detection of liver fibrosis and cirrhosis in the CHC patients are helpful for diagnosis and follow up of those patients. This study was conducted on 60 Egyptian patients with CHC in the period between September 2014 and February 2016. Our studied patients were recruited from Ain Shams University Hospitals during their preparation for antiviral treatment. We tested the diagnostic value of Ultrasound Scoring System Score (USSS) compared to liver stiffness measurement by Transient Elastography in diagnosis of liver fibrosis and cirrhosis in our studied patients. Histological examination of liver biopsy was the standard of care till that time to compare with in all patients in addition to other laboratory parameters including CBC, liver function tests, viral load by quantitative PCR. 38 patients were males (63.3%) and 22 were females (36.7%), with mean age mean 43.45 +- 18.164 years (range from 24-65 years). BMI was 27.8+-4.03 kg/m2. 2 patients showed F0 stage of fibrosis in their liver biopsy, 7 patients