Study of Hypoparathyroidism in Beta-Thalassemia Major Children & Adolescents and its Relation to Type of Chelation Therapy

Abstract

Background: Beta thalassemia major (BTM) constitutes a major public health problem in Egypt. Early diagnosis of iron overload complications such as hypoparathyroidism could prevent other sever disorders such as seizures, osteopenia, and osteoporsis. Aim of the work: To determine the prevalence of hypoparathyroidism in patients with BTM in relation to iron chelation therapy. Subjects and Methods: This is a cross sectional study, 60 patients with thalassemia major recruited with mean age of 12.47±3.63 years, M:F (45%:55%) who are transfusion-dependant regularly attending Hematology Clinic, Children’s Hospital, Ain-Shams University. Diagnosis of HPT was based on low serum calcium (S/Ca), high serum phosphate (Po4), and low serum parathyroid hormone levels. Other parameters analyzed included age, sex, serum ferritin levels, weight, height, transfusion history, any symptoms of hypocalcemia, and presence of other complications in these patients.