Hodgkin Lymphoma: A Retrospective Clinical and Pathological Analyses with correlation to Treatment Outcome

Abstract

To conclude, some of the results of our study are comparable with the previous studies. Some of the parameters in our study were not statistically significant such as age, sex, B symptoms despite being significant in previous studies. Advanced Stage, bulky and extranodal disease were found to affect both the OS and PFS so that risk-adapted treatment can be adopted at different stages. To give an example, treating an elderly male with bulky stage III disease accompanied with B symptoms and high ESR would be different than treating a young female with localized non bulky cervical stage IA disease in terms of number of chemotherapy cycles, dosage of radiotherapy if used or the use of frontline aggressive regimens. Inflammatory markers were found to be related to response to treatment and survival in the current and previous studies respectively. Same was noted with pathological subtype. Also, leucocytosis and lymphopenia had a significant negative effect on response rates and survival.