ROLE OF TNF-a AND ANTICYTOKINES "PENTOXIFYLLINE" IN DIABETIC NEPHROPATHY WITH MICROALBUMINURIA

Abstract

Diabetic nephropathy (DN) is a major complication of diabetes, which affects up to a half of diabetics world wide. Microalbuminuria is a predictor for the development of clinical diabetic nephropathy.

The pathogenesis of DN is a complex, multifactorial process, that is initiated by the interaction between hyperglycemia and a number of genetic and aqueried risk factors, and mediated by a net work of cytokines.

TNF- a may play a significant role in renal damage of patients with

DN. through different mechanisms.

Pentoxifylline was reported to reduce, microalbuminuria- through its capacity to reduce circulating levels ofTNF- a.

The aim of the present work was to study correlation between TNF- a and microalbuminuria befor and after pentoxifylline treatment in type 2 diabetic patients with microalbuminuria.

The study was conducted on 2 groups

Group 1: 20 type 2 diabetic patients with microalbuminuria.

Group II: 10 normal controls of average age and sex.

The diabetic patients and the control group were subjected to:

I- Through history taking and complete clinical examination with stress on the duration of diabetes and history of urinary troubles.