Study of the effect of combined antischistosomal drugs on different strains of semansoni infected albino mice

Abstract

Schistosamiasis is a widespread disease to affect 200 million people. Numerous approaches have been attempted to reduce the transmission of infection and the morbidity of the disease.

Chemotherapy is recommended as an effective mean of controlling schistosomiasis. Referring to the possibility of appearance of drug resistant parasites, specially with re-treatment regimens in endemic areas, search for new schistosomicidals is essential .

Chemotherapeutics are sometimes used in combination to obtain a better therapeutic response with smaller doses of each drug and thus we can reduce the likelihood of side effects.

In the present work, the effect of combined reduced dose of two oral antibilharzial drugs (praziquantel and Ro 15-5458) on the susceptible and non-susceptible strains of .mansoni infected albino mice was studied .