A Novel Approach For Prevention Of Severe Ovarian Hyperstimulation Syndrome (Ohss) In Highly Suspected Cases

Abstract

BACKGROUND:Ovarian hyperstimulation syndrome (OHSS) is the most serious and potentially life-threatening iatrogenic complication associated with ovarian stimulation during assisted reproductive technology protocols. The moderate and severe forms may occur in 3% to 10% of all assisted reproductive technique (ART) cycles, and the incidence may reach 20% among high-risk women This study was performed to evaluate the effect of single puncture to retrieve 6 or 7 eggs only to prevent severe Ovarian hyperstimulation syndrome in women at high risk in in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) treatment cycles. METHODS: Thirty women at risk to develop severe OHSS undergoing IVF/ICSI treatment cycle were included in this prospective study grouped into two groups, each group contains fifteen patients. The study group, single ovarian puncture retrieving about 7 eggs only was done in comparison to the control group who undergo retrieval of all eggs. The prevention of severe OHSS was the primary outcome. RESULTS:The incidence of severe OHSS was 13.3% in the study group and 73.3% in the control group. Thus, the incidence of OHSS was significantly reduced, in the study group in comparison with the control group. CONCLUSION: Single puncture retrieving about 7 eggs only, reduces the incidence of OHSS in women at high risk undergoing IVF/ICSI treatment. Key Words:Prevention, Ovarian Hyperstimulation Syndrome (Ohss)