EXTENSIVE PlATELET ACTIVATION AND ENHANCED EXPRESSION OF CEll ADHESION MOlECUlES IN PREEClAMPSIA
Osama Ahmed Hamdy Mansur;
Abstract
The aim the study is to investigate by means of flow
• cytometry using a panel of activation markers the extent of platelet activation in normal pregnancy and whether this activation is more extensive during preeclampsia or not -
Our study was conducted on two groups of females;
Group 1: pre-eclamptic patient in third trimester.
Group II:Normotensive- third trimester pregnant female.
By flow cytometry, we investigate for the following markers.
• Anti CD61; pan platelet marker, for gating of platelets in the three-colour analysis (Per CP) .
• PAC-1; Monoclonal antibodies against fibrinogen receptor conformation of glycoprotein lib /lila complex (fluorescein isothiocynate) (FITC)
• Anti CD62; (P-selectin, (Phycoerythrin) (PE)
• Anti CD63; GP52,lysosomal secretion.(FITC)
• Anti CD31 (PECAM-1); GPIIIa platelet endothelial cell adhesion molecule- I (FITC).
• cytometry using a panel of activation markers the extent of platelet activation in normal pregnancy and whether this activation is more extensive during preeclampsia or not -
Our study was conducted on two groups of females;
Group 1: pre-eclamptic patient in third trimester.
Group II:Normotensive- third trimester pregnant female.
By flow cytometry, we investigate for the following markers.
• Anti CD61; pan platelet marker, for gating of platelets in the three-colour analysis (Per CP) .
• PAC-1; Monoclonal antibodies against fibrinogen receptor conformation of glycoprotein lib /lila complex (fluorescein isothiocynate) (FITC)
• Anti CD62; (P-selectin, (Phycoerythrin) (PE)
• Anti CD63; GP52,lysosomal secretion.(FITC)
• Anti CD31 (PECAM-1); GPIIIa platelet endothelial cell adhesion molecule- I (FITC).
Other data
| Title | EXTENSIVE PlATELET ACTIVATION AND ENHANCED EXPRESSION OF CEll ADHESION MOlECUlES IN PREEClAMPSIA | Other Titles | زيادة نشاط الصفائح الدموية وزيادة ظهور جزيئات الخلايا الملتصقة فى مرضى تسمم الحمل | Authors | Osama Ahmed Hamdy Mansur | Issue Date | 2001 |
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