Insulin-Like Growth Factor 1 and it’s Role in the pathogenesis of acne vulgaris
Heba Mahmoud Hassan;
Abstract
Acne vulgaris is a common disease with prevalence reaching up to 80% during adolescence. It is characterized by chronic inflammation of the pilosebaceous units with the formation of comedones, erythematous papules and pustules and sometimes nodules or cysts.
The pathogenesis of acne is often associated with several factors, including increased sebum production, altered differentiation of the pilosebaceous duct, follicular colonization by P. acnes and development of inflammation.
Human sebaceous glands are found over the entire skin surface (except the palms and soles), but sebum secretion is highest on the scalp, face, chest, and back. The most obvious function of the sebaceous gland is to secrete sebum.
Sebaceous gland functions, which are possibly involved in the development of acne, are production of sebum, regulation of cutaneous steroidogenesis, regulation of focal androgen synthesis, interaction with neuropeptides, synthesis of specific lipids with antimicrobial activity and exhibition of pro - and anti-inflammatory properties.
Sebum production is continuous and is not controlled by neural mechanisms. Retinoids, hormones and growth factors influence sebaceous growth and differentiation. Androgens and growth hormone promote the differentiation of sebaceous glands where as estrogens and retinoids inhibit their differentiation.
Secreted by the pituitary gland, growth hormone acts on the liver and peripheral tissues to stimulate the production of insulin-like growth factor-1 (IGF-1), formerly known as somatomedin-c. It has been hypothesized that growth hormone may be involved in the development of acne (Rosenfield and Deplewski, 1995).
The effects of DHT is likely synergized by IGF-1, an adolescence- related growth factor, whose pubertal rise peaks at 15 years in girls and 18 years in boys, and subsequently fall to basal level. IGF-1 is closely associated with the course of clinical acne (Smith et al., 2007).
In addition, IGF-1 can be produced locally within the skin, where it can interact with receptors on the sebaceous gland to stimulate its receptors on the sebaceous gland to stimulate its growth. Furthermore, conditions of growth hormone excess, such as acromegaly are associated with seborrhea and the development of acne. In some tissues, the actions of IGF-1 can be mediated by androgens. It is possible that androgens may influence IGF-1 action in the sebaceous gland as well (Cappel et al., 2005).
The pathogenesis of acne is often associated with several factors, including increased sebum production, altered differentiation of the pilosebaceous duct, follicular colonization by P. acnes and development of inflammation.
Human sebaceous glands are found over the entire skin surface (except the palms and soles), but sebum secretion is highest on the scalp, face, chest, and back. The most obvious function of the sebaceous gland is to secrete sebum.
Sebaceous gland functions, which are possibly involved in the development of acne, are production of sebum, regulation of cutaneous steroidogenesis, regulation of focal androgen synthesis, interaction with neuropeptides, synthesis of specific lipids with antimicrobial activity and exhibition of pro - and anti-inflammatory properties.
Sebum production is continuous and is not controlled by neural mechanisms. Retinoids, hormones and growth factors influence sebaceous growth and differentiation. Androgens and growth hormone promote the differentiation of sebaceous glands where as estrogens and retinoids inhibit their differentiation.
Secreted by the pituitary gland, growth hormone acts on the liver and peripheral tissues to stimulate the production of insulin-like growth factor-1 (IGF-1), formerly known as somatomedin-c. It has been hypothesized that growth hormone may be involved in the development of acne (Rosenfield and Deplewski, 1995).
The effects of DHT is likely synergized by IGF-1, an adolescence- related growth factor, whose pubertal rise peaks at 15 years in girls and 18 years in boys, and subsequently fall to basal level. IGF-1 is closely associated with the course of clinical acne (Smith et al., 2007).
In addition, IGF-1 can be produced locally within the skin, where it can interact with receptors on the sebaceous gland to stimulate its receptors on the sebaceous gland to stimulate its growth. Furthermore, conditions of growth hormone excess, such as acromegaly are associated with seborrhea and the development of acne. In some tissues, the actions of IGF-1 can be mediated by androgens. It is possible that androgens may influence IGF-1 action in the sebaceous gland as well (Cappel et al., 2005).
Other data
| Title | Insulin-Like Growth Factor 1 and it’s Role in the pathogenesis of acne vulgaris | Other Titles | عـــامل النمو شبيه الأنسولين-1 ودوره فى مرض حب الشباب | Authors | Heba Mahmoud Hassan | Issue Date | 2015 |
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