Effect of Mesenchymal Stem Cells Injection on Induced Stomatitis in Chemotherapy Treated Rats

Abstract

The goals of chemotherapy induced mucositis management are to prevent or reduce the severity of the drug toxicity and to manage the associated symptoms. Mucositis management allows the continued delivery of treatment without interruption or dose reduction leading to improvement of overall prognosis. But unfortunately there is no standard protocol that is used to completely cure or prevent oral mucositis. Nowadays stem cells are a subject of interest as a potentially revolutionary new way to treat diseases and injuries, with wide-ranging medical benefits as wound healing, ulcer treatment and management of side effects of chemotherapy. So, this study was evaluating the effect of intravenous injection of mesenchymal bone marrow stem cells on induced stomatitis in rats receiving chemotherapy. 56 male Wister rats weighting around 250 grams were used in the present study. Mesenchymal bone marrow stem cells (MBSCs) were purchased from biochemistry department in faculty of medicine Cairo University which was were labeled with PKH26 die. While 5-Fluorouracil was used as a chemotherapeutic drug. Rats were divided into 4 groups (3 experimental and 1 control): Group 1: Rats were ex