THE DYNAMIC OF GLUCOSE-INSULIN ENDOCRINE METABOLIC REGULATORY SYSTEM: A SYSTEM DYNAMICS APPROACH

Abstract

Diabetes mellitus is a disease in the glucose-insulin endocrine metabolic . regulatory system, in which the pancreas either does not release insulin or does not properly use insulin to uptake glucose in the plasma, which is referred as hyperglycemia. Complications of diabetes mellitus include retinopathy, nephropathy, peripheral neuropathy and blindness. Diabetes mellitus is one of the worst diseases with respect to size of the affected Population. According to the data published by the Egyptian Ministry of Health and Population and the United States Agency for International Development, the total number of persons with diagnosed and undiagnosed diabetes in Egypt will increase from 3.24 million in 1995 to 3.80 million in 2000 and to 8.80 million by the year 2025.

The economic impact of diabetes is staggering Total costs of diabetes in the U.S. in

2002 were estimated to be $132 billion.

Due to the large population of diabetes patients in the world and the big health expenses, many researchers are motivated to study the glucose-insulin endocrine metabolic regulatory system so that we can better understand how the mechanism functions, what cause the dysfunctions of the system, how to detect the onset of the either type of diabetes.